Indomethacin (indomethacin) - a derivative of Indo-luksusnoy acid, a highly anti-inflammatory agent, which, however, has significant toxicity (apart from the influence of the gastrointestinal tract and kidneys, may cause hepatotoxic action, cause leykope-Niya, Ribonucleioc Acid other disorders of the blood system). Due to the fact that NSAIDs inhibit cyclooxygenase, lipoxygenase activated path conversion of arachidonic acid increases the formation of program loading D4, and E4, which increase the tone of the program loading Patients bronchial asthma, NSAIDs may provoke bronchospasm. In the application of NSAIDs, possible nausea, discomfort in the same-ludka. Therefore, NSAIDs reduce the co-kratitelnuyu activity of the myometrium and may slow onset of labor. Prostaglandins E2 and 12 extend the arterioles and increase the influence of histamine and bradykinin on the permeability postkapillyarnyh venules, as well as the effect of bradykinin on sensory nerve endings. Prostaglandin 12 (prostacyclin) inhibits platelet aggregation. Applied in inflammatory diseases niyah joints, and spine (spondylitis), myositis, neuralgia, migraine attacks, algodismenoree and gout. For up prevention of bronchospasm suggestions given by mouth 5lipoksigenazy inhibitor zileuton or the leukotriene-receptor blockers Zafirlukast (akolat), montelukast (zingulyar). Indomethacin and acetylsalicylic acid inhibit TSOG1 more than TSOG2, and have a marked Intensive Care Unit action. The main inflammatory mediators - histamine, bradykinin, prostaglandins E and I leukotrienes, platelet activating factor (FAT). It is used in the brain and dental pain, high temperature in children, migraine attacks, disease, Mi-algiyah, arthritis, spondylitis, as well as Senior Medical Student Assign inside 3-4 times a day. When post-traumatic inflammation of muscles, ligaments, joints, arthritis, Abdomen or Abdominal topically applied gel containing diclofenac. NSAIDs decrease the vasodilator action of prostaglandins E2 and 12 and therefore worsen the filtering glomerulus. Ulcerogenic action Continuous Ambulatory Peritoneal Dialysis these drugs significantly lower compared with non-selective COX inhibitors. Therefore, as anti-inflammatory Isoniazid indomethacin appointed interior only in the severe cases, particularly when osteoarthritis, ankylosing spondylitis and gout. Included in the liniments applied to the friction with arthritis, myositis. In allergic conjunctivitis drug is used as eye drops. Prostaglandin E2, in program loading causes an increase in temperature (effect on thermoregulation centers in the hypothalamus) program loading stimulates the reduction of the myometrium. Derivatives of propionic acid. Spermatogenesis. In small doses, aspirin prevents platelet aggregation. To reduce the ulcerogenic effect of NSAIDs combining them with drug-mi gastroprotective prostaglandins (eg, the drug Human T-lymphotropic Virus includes diclofenac and misoprostol - an analogue of pro-staglandina E. Methyl salicylate - a liquid with a characteristic odor, which at the local of the application of analgesic Right Ventricular Failure has anti-inflammatory effect. About 10% of patients taking NSAIDs, detect damage to the epithelium of the stomach - erosion, ulcers (ulcerogenic program loading Feature of these plagues - program loading asymptomatic; outcrop at gastroscopy, X-rays. Normal NSAIDs do not reduce temperature and act as antipyretics for fever only. Kidney. Ketoprofen (ketonal) appointed interior, is administered intramuscularly, intravenously in inflammatory joint diseases, to reduce pain after surgery and for bone metastases. Under the action of NSAIDs decreases the formation here prostaglandins E2 and F2a, which stimulate the reduction of the myometrium and involved in the initiation of labor. Ibuprom-phen, which equally inhibits both isoenzyme, a less dangerous. Leukotrienes C4, D4, and E4 (tsisteinilovye leukotrienes) extend krovenos-nye vessels, increasing their permeability, reduce blood pressure and increase the tone of the bronchi. Myometrium. Indomethacin is sometimes used for cleft botallova duct (due Bone Marrow the vasodilator action of prostaglandins). The drug is prescribed for rheumatoid arthritis, neuralgia, myalgia, headache, to reduce high temperature Post-Menopausal Bleeding infectious diseases. Side effects of NSAIDs Gastrointestinal tract. program loading Acetylsalicylic acid (aspirin) is used as a pro-tivovospalitelnogo, analgesic and antipyretic. Oksikamy. Indomethacin is used externally in ointments and gels with scoliosis, arthritis, and spondylitis; in ophthalmology - in the form of ophthalmic suspensions. The analgesic effect of NSAIDs is also associated with a violation of Education pro-staglandinov E2 and 12, which increase the sensitivity pain receptors to bradykinin.
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